Report of SRI activities and Impact for
the year October 2022 to October 2023.
Executive Summary
q Our reviews have contributed to 20 international
and national guidelines and the Transfusion Evidence Library has been
referenced in at least 26 published papers.
q There have been three new research
grant applications made and one new clinical trial started using evidence from
one of our systematic reviews [see details on page 16 and 17].
q Eleven full systematic reviews were
completed and published [see citations detailed on page 2].
q A further four full systematic review
are going through peer review [see details on page 3].
q We have continued our collaboration with ISBT, including a new Journal Club
webinar to discuss The Transfusion
Evidence Round-Up [see details on page 6].
q We
have been working with others in NHSBT to find a way to build a website for the
SRI.
q We
have increased the variety of our engagement activities this year [see details
on pages 6 to 9].
q We have continued to grow our Twitter/X
accounts [@TransfusionLib, @sritransfusion
and @stemcell] to engage with our library communities and increase our
dissemination activities.
How does this year’s output and impact
compare to last year?
· We have published a similar number of
reviews [11 compared to 12] and have two reviews going through peer review [five
last year].
· We have found less evidence of the
citing of our reviews in new guidelines [20 guidelines compared to 29 last
year] with less of our reviews cited [18 reviews compared to 30 last year].
· The Transfusion Evidence Library has
been referenced in more journal publications [26 compared to 18].
· The Transfusion Evidence Library is
provided as a resource for users on more independent sites [14 compared to 10].
· Overall, there have been a
greater variety of, and more engagement in, activities this year than during 2021/2022.
·
The number of followers for each
Twitter/X account has increased - by 9% for Transfusion Evidence Library, 10%
for the SRI and 25% for Stem Cell Evidence: all are similar increases to the
increases seen between November 2021 and October 2022.
|
Section |
Our Evidence |
|
Publications since November 2022 listed
alphabetically by first author. [Authors in bold are
members of the SRI] Explanations of Complexity
descriptors A
simple review includes only RCTs and includes <10 RCTs. A
medium review includes only RCTs and includes between 10 and 100 RCTs.
Or a review of mixed study types with no risk of bias and statistical
analysis. A complex review can be any of the following
includes non-randomised studies; uses methodology such as IPD individual patients data] or NMA [network meta-analysis]; includes
more than 100 eligible studies or is a significant update of an already
published systematic review, for example requires a total rewrite of methods
and therefore extraction and analysis of already included data. Black = only involvement
was the search |
3 Complex reviews; 5
medium reviews; 3 simple reviews; 2 search support Beverly A, Ong G, Kimber C, Sandercock J, Dorée C,
Welton NJ, Wicks P, Estcourt LJ. Drugs to reduce bleeding and
transfusion in major open vascular or endovascular surgery: a systematic
review and network meta-analysis. Cochrane Database of Systematic Reviews.
2023 Feb 17;2(2):CD013649. doi: 10.1002/14651858.CD013649.pub2. [Number of
included studies = 22]. Dhiman P, Ma J, Gibbs VN, Rampotas A, Kamal
H, Arshad SS, Kirtley S, Doree C, Murphy MF, Collins GS, Palmer AJ.
Systematic review highlights high risk of bias of clinical prediction models
for blood transfusion in patients undergoing elective surgery. Journal of
Clinical Epidemiology. 2023 May 6:S0895-4356(23)00108-7.
doi: 10.1016/j.jclinepi.2023.05. 002. SEARCH ONLY Geneen LJ, Dorée C, Estcourt LJ. Interventions for improving adherence to
iron chelation therapy in people with sickle cell disease or thalassaemia.
Cochrane Database of Systematic Reviews. 2023 Mar 6;3(3):CD012349. doi:
10.1002/14651858.CD012349.pub3. [Number of included studies = 4]. Gibbs VN, Geneen LJ, Champaneria R, Raval P, Dorée C, Brunskill SJ,
Novak A, Palmer AJ, Estcourt LJ. Pharmacological interventions for the
prevention of bleeding in people undergoing definitive fixation or joint
replacement for hip, pelvic and long bone fractures. Cochrane Database
of Systematic Reviews. 2023 Jun 5;6(6):CD013499. doi:
10.1002/14651858.CD013499.pub2. [Number of included studies = 13]. Kimber C,
Lamikanra AA, Geneen LJ, Sandercock J, Dorée C, Valk SJ, Estcourt
LJ. A systematic review of the safety and efficacy of convalescent plasma
or immunoglobulin treatment for people with severe respiratory viral
infections due to coronaviruses or influenza. Transfusion Medicine 2023
Feb;33(1):26-38. doi: 10.1111/tme.12942. [Complex due to the inclusion of RCT and non RCT
data. Number of included studies = 32]. Kimber C, Valk SJ, Chai
KL, Piechotta V, Iannizzi C, Monsef I, Wood EM, Lamikanra AA, Roberts DJ,
McQuilten Z, So-Osman C, Estcourt LJ, Skoetz N. Hyperimmune
immunoglobulin for people with COVID-19. Cochrane Database of Systematic
Reviews 2023 Jan 26;1(1):CD015167. doi:
10.1002/14651858.CD015167.pub2. Number of included studies = 5]. Iannizzi C, Chai KL, Piechotta V, Valk SJ, Kimber
C, Monsef I, Wood EM, Lamikanra AA, Roberts DJ, McQuilten Z, So-Osman C,
Jindal A, Cryns N, Estcourt LJ, Kreuzberger N, Skoetz N. Convalescent
plasma for people with COVID-19: a living systematic review. Cochrane
Database of Systematic Reviews. 2023 May 10;5(5):CD013600. doi:
10.1002/14651858.CD013600.pub6.
[Number of included studies =
33]. Lin, V.S., Sun, E., Yau, S. Abeyakoon C,
Seamer G, Bhopal S, Tucker H, Doree C, Brunskill S, McQuilten Z,
Stanworth S, Wood E, Green L. Definitions of massive transfusion in
adults with critical bleeding: a systematic review. Critical Care. 2023 Jul
5;27(1):265. doi: 10.1186/s13054-023-04537-z. [Number of included studies =
30]. Lloyd TD, Geneen LJ, Bernhardt K, McClune
W, Fernquest SJ, Brown T, Dorée C, Brunskill SJ, Murphy MF, Palmer AJ.
Cell salvage for minimising perioperative allogeneic blood transfusion in
adults undergoing elective surgery. Cochrane Database Syst Rev. 2023 Sep
8;9(9):CD001888. doi: 10.1002/14651858.CD001888.pub5. [Complex due to this being a significant update.
Number of included studies = 106]. McCullagh J, Cardigan R, Brunskill SJ,
Bullock T, Doree C, Estcourt L, Huish S, Sandercock J, Green L.
Assessing the risks of haemolysis as an adverse reaction following the
transfusion of ABO incompatible plasma-containing components - A scoping
review. Blood Reviews. 2022 Nov; 56:100989. doi: 10.1016/j.blre.2022.100989.
[Complex due to the mix of included study types. Number of included studies =
49]. Mo A, Poynton M, Wood E, Shortt J, Brunskill
SJ, Doree C, Sandercock J, Saadah N, Luk E, Stanworth SJ,
McQuilten Z. Do anemia treatments improve quality of life and physical
function in patients with myelodysplastic syndromes (MDS)? A systematic
review. Blood Reviews.2023 Sep;61:101114. doi: 10.1016/j.blre.2023.101114.
[Number of included studies = 26]. Roy NB, Carpenter A, Dale-Harris I, Dorée
C, Estcourt LJ. Interventions for chronic kidney disease in people with
sickle cell disease. Cochrane Database of Systematic Reviews. 2023 Aug
4;8(8):CD012380. doi: 10.1002/14651858.CD012380.pub3. [Number of included
studies = 3] Schofield J, Hosseinzadeh S, Burton K, Pavord
S, Dutt T, Doree C, Lim WY, Desborough MJR. Drug-induced thrombotic
thrombocytopenic purpura: A systematic review and review of European and
North American pharmacovigilance data. British Journal of Haematology. 2023
May;201(4):766-773. doi: 10.1111/bjh.18577. SEARCH ONLY Going through peer review: · Strategies
for use of blood products for major bleeding in trauma
(Cochrane) · Restrictive versus liberal red blood cell
transfusion strategies for people with haematological malignancies treated
with intensive chemotherapy. · Rh D review |
|
Collaborations with people outside the SRI. These have
been grouped by type of project. New collaborators this year
are identified by an * at the beginning of their details. |
We have collaborated with many clinicians and researchers over
the last 12 months. Their names and affiliations are provided here: Stem Cell Evidence: Dr James Griffin – NHSBT, UK. Mr John Muth - Evidentia Publishing, UK. Mr Mark Schregardus – Evidentia Publishing, The Netherlands. Mr Michael Studman - Evidentia Publishing, UK. NIHR Cochrane Programme Grant *Cochrane Editorial Unit Cochrane Injuries Group [co-applicant]. Cochrane Vascular Group. Dr Nikki Curry - Oxford University Hospitals NHS
Foundation Trust, UK [co-applicant]. Toby Lasserson – Cochrane Editorial Unit. Clareece Nevill – NIHR Complex Reviews Support Unit *Professor Alex Sutton – University of Leicester Professor Nicky Welton – University of Bristol. Transfusion Evidence Round-Ups Dr Gwen Clarke – University of Alberta, Calgary, Canada. Beatriz
Galindo – ISBT Central Office, The Netherlands.
Dr Allison Mo - Monash University, Melbourne, Australia.
Marion
Molliet – ISBT Central Office, The Netherlands.
Jenny White – Executive Director, ISBT, The Netherlands. Professor Erica Wood - Transfusion
Research Unit, Melbourne, Australia. Eszter
Herczenik – ISBT Central Office, The Netherlands.
Systematic review collaborators: *Dr Alisha
Allana - University Hospital Southampton
NHS Foundation Trust, UK. Keeley Bernhardt - Medical student, University of Oxford,
Oxford, UK. Dr Cath Booth – Royal Barts NHS Trust, UK. *Dr Lorna Cain – NHSBT, UK. Dr Rebecca Cardigan - NHSBT, UK. Dr Nikki Curry - Oxford University Hospitals NHS
Foundation Trust, UK. *Katerina Dangas - Medical student, University of Oxford,
Oxford, UK. Dr Michael Desborough - Oxford University Hospitals NHS
Foundation Trust, UK. Paula Dhiman – University of Oxford, Oxford, UK. *Matilda Dichmont - Medical student, University of Oxford,
Oxford, UK. Dr Vishakha Erasu - Oxford University Hospitals NHS Foundation
Trust, UK. A/Prof Jez Fabes – Peninsula Medical School & Derriford
Hospital, Plymouth, UK. Dr Scott Fernquest - University of Oxford, Oxford, UK. Professor Laura
Green – NHSBT & Barts Health NHS Trust, UK. Dr Aqib Hafeez - Oxford University Hospitals NHS
Foundation Trust, UK. *Dr Youngjoo Kang – Royal Berkshire Hospital, Reading, UK. *Dr Alvin Katumba - Oxford University
Hospitals NHS Foundation Trust, UK. Dr Abi Lamikanra - NHSBT,
& University of Oxford, Oxford, UK. Dr Victor Lin – The Royal Melbourne Hospital, Australia.
Dr Tom Lloyd - Oxford University Hospitals NHS Foundation Trust,
UK. Dr Eleni Louka - Great Ormand Street Hospital, London, UK. William McClune – Medical student, University of Oxford, Oxford,
UK. *Dr Thomas McGrath – Great Ormand Street Hospital, London, UK. Professor Zoe McQuilten - Monash University, Melbourne, Australia. *Mr. Devender Mittapalli - University
Hospitals Plymouth NHS Trust, UK. Dr Allison Mo - Monash University, Melbourne, Australia. Dr Gaurav Nigam - Oxford University Hospitals NHS Foundation
Trust, UK Dr Alex Novak - Oxford University Hospitals NHS Foundation
Trust, UK Dr Antony Palmer – University of Oxford and Oxford University
Hospitals NHS Foundation Trust, UK Vanessa Piechotta – Cochrane Haematology, Cologne, Germany. *Dr Matthew Poynton - Oxford University Hospitals NHS Foundation
Trust, UK. Sue Proffitt - NHSBT, UK. Mr Parag Raval – University Hospitals of Leicester, UK. A/Professor Noemi Roy - Oxford University Hospitals NHS
Foundation Trust, UK Professor David J Roberts – NHSBT and University of Oxford, UK Dr Akshay Shah - Oxford University Hospitals NHS
Foundation Trust, UK Dr Nicole Skoetz – Cochrane Cancer, Cologne, Germany. Dr Cynthia So-Osman – Erasmus Medical Center, The Netherlands. *Dr Sam Tingle - Dr Harriet Tucker – St George’s University Hospital, London, UK Dr Kirstin Wilkinson – University
Hospital Southampton NHS Foundation Trust, UK. Dr Mike Wiltshire - NHSBT,
UK. Professor Erica
Wood - Transfusion Research Unit,
Melbourne, Australia. |
|
Further Funding |
Three funding applications were made between October 2022 and October
2023: 1.
Susan Brunskill and Professor Simon
Knight [transplant surgeon, Oxford University NHS Foundation Trust] applied
to NHSBT small grants for money to both fund the sole member of salaried
staff working on the Transplant Library and cover costs to make the Transplant
Library free to access in the UK [February 2023]. The application was for £75,594.60.
This application was unsuccessful as it did not rank high enough
against other applications. 2.
Susan Brunskill applied to NHSBT
NIHR Research Capability Funds in May 2023 for the salary costs for the sole
member of salaried staff working on the Transplant Library for the period
July 2023 through to March 2024. The application was for £47,000. The application
was successful. 3.
Lise Estcourt applied for a further
extension to the SUPPORT E programme grant in spring 2023. The application
was successful. |
|
Next Destination & Skills |
No one has left the SRI within the
last 12 months. |
|
Engagement Activities |
Transfusion Evidence Round-Up In 2021, we have teamed up
with ISBT to produce a quarterly Transfusion Evidence Round-Up. Four Round-Ups
have been published in the last 12 months: · The
Best of the Transfusion Evidence Library (5th December 2022) · World
Haemophilia Day (6th March 2023) · World
Blood Donor Day (14th June 2023) · World
Heart Day (29th September 2023). New to this year is that all Round-Ups are followed up by a live,
one hour webinar, co-chaired by Dr Allison Mo and the SRI team. During these
webinars, each of the three members of the ISBT community who chose the 10
references for the Round-Up, talk through their ‘top’ record of the 10 selected
records. The webinars are hosted by ISBT and are open to anyone within the
ISBT community. As the World Blood Donor Day Round-Up coincided with the ISBT
international congress, a live webinar was held during the congress. Lise
Estcourt represented the SRI at this event and helped to facilitate a
workshop within the webinar, which saw attendees assess the merits of several
papers and choose their top paper from the set they were given. We have had
very positive feedback from all webinars and plan to continue running them
through 2024. Each Round-Up is promoted
on Twitter/X through the SRI, Transfusion Evidence Library and ISBT feeds. We
have reviewed analytics data following each Round-Up and take up is similar
to that of the monthly evidence alerts. Social media activity: We run 3 Twitter/X accounts, one for each of our electronic
libraries and one for the SRI overall. Our activity on these accounts is one
of the aspects of our online presence strategy. We
also run a Facebook account for each of the libraries and have also created
Mastodon accounts for each library, although our primary focus remains
Twitter/X. Our Twitter/X accounts have a combined total of 6427
followers: · 548 [up from 503 in October 2022] for Stem Cell Evidence · 3303 [up from 3085 in October 2022] for Transfusion Evidence
Library · 576 [up from 458 in October 2022] for SRI. To increase engagement, this year we have started doing the
following: · Creating
visual infographics for each newly published systematic review and sharing
through our Twitter/X accounts and internally through ‘Viva Engage’ · Sharing
the PICO summary for each record featured in our monthly Evidence Alerts and
quarterly Round-Ups on our library Twitter/X accounts. Talks, Podcasts and Presentations: Members of the SRI have given the
following talks over the last year: · Lise Estcourt on Future of Transfusion to RCPath
Advances in Transfusion (International), virtual, November 2022 · Lise Estcourt on Red cell shortages, key issues
& actions to RCPath Advances in Transfusion (International), virtual,
November 2022 ·
Lise Estcourt on
Pathogen-reduced platelets for the prevention of bleeding, to IPFA/PEI
workshop (International), Italy, May 2023 ·
Susan Brunskill on
‘Systematic Review Initiative: core ongoing work and our plans for the year
ahead’ to NHSBT clinical research teams, virtual, March 2023. ·
Lise Estcourt on
SUPPORT E recommendations to a Support E conference, Belgium, June 2023 ·
Lise Estcourt on
ISBT/Transfusion Evidence Library round-up workshop, ISBT Congress June 2023,
(International), Sweden ·
Josie Sandercock workshop
with the Complex Reviews Support Unit (Leicester) on “MetaInsight: An
interactive user-friendly “point and click” web application to conduct
network meta-analysis” to Cochrane [Colloquium], London, September 2023 · Louise
Geneen on ‘How could the output from a NIHR Programme Grant tackle
health inequalities: Findings from four systematic reviews undertaken by the
Systematic Review Initiative since 2018’ to NHSBT R&D
Conference, Birmingham, October 2023 Presented posters at the following conferences: · Lise Estcourt on ‘Introducing ‘Transfusion Evidence
Round-ups’: a collaboration between ISBT and the Systematic Review
Initiative, born of a common goal to share knowledge to improve worldwide
practice of transfusion medicine’ to ISBT Congress, Sweden, June 2023 · Catherine Kimber and Alicia Plaza Cajide to SHOT
on our evidence libraries, Manchester, July 2023 · Josie Sandercock, Louise Geneen,
Catherine Kimber on
‘Competing events and in-hospital follow up: issues to be aware of’ to
Cochrane [Colloquium], London, September 2023 · Josie Sandercock and Louise Geneen on ‘Analysis of a continuous outcome
when the data includes a large proportion of zeros’ to Cochrane [Colloquium],
London September 2023 · Susan Brunskill on ‘Transfusion Evidence Round-ups’: an ISBT/SRI collaboration with a goal to share knowledge to improve transfusion practice worldwide’ to Cochrane [Colloquium], London, September 2023 · Catherine Kimber and Susan Brunskill on ‘How the
‘Transfusion Evidence Round-Ups’, a Collaboration Between the Systematic
Review Initiative and ISBT, can Help to Tackle Health Inequalities in
Transfusion Medicine’ to NHSBT R&D Conference, Birmingham, October
2023 · Louise Geneen on “Cell Salvage for minimising
perioperative allogeneic blood transfusion in adults undergoing elective
surgery: Recorded podcasts for
Cochrane: · Louise Geneen, ‘Can collecting blood
that is lost during surgery, and returning it to the patient, reduce the need
to use donated blood for that patient?’, using data from the Cochrane cell
salvage review, in September 2023. Our reviews have been the focus of a talk by someone outside of
the SRI: ·
Dr Victor Lin ‘What is a
massive transfusion? A scoping review to inform an international consensus
definition’ to the European Hematology Association conference, June 2023. Teaching and
support activities that the SRI staff provide to Clinical Fellows and other
staff through the year.
All systematic reviewers within the SRI have provided training
on systematic review processes and methodology for all our completed and
ongoing systematic reviews. Further, we have: ·
Provided training on how to use Covidence for screening for all
new reviewers [as asterixed in ‘Systematic Review Collaborators on pages 4
and 5]: all SRI team members. ·
Provided project management support and advice to a new Clinical
Fellow, Dr Lorna Cain: Louise Geneen ·
Provided training on ‘how to do an overview’ to Dr Alwyn Kotze:
Lise Estcourt ·
Co-developed a Risk of Bias tool for laboratory studies and
provided data management support for the Universal Irradiation systematic
review: Louise Geneen, Josie Sandercock, Lise Estcourt. ·
Provided support on how to use RevManWeb to Dr Noemi Roy and
colleagues: Susan Brunskill and Lise Estcourt; and to Dr Tom Lloyd: Louise Geneen. ·
Providing statistical advice on two research projects being
undertaken by Professor Simon Stanworth: Josie Sandercock. SRI website. For the past ten years, our SRI website has been a sub-site of
the JPAC transfusion guidelines website https://www.transfusionguidelines.org/systematic-review-initiative
Over the last few years we have explored different options to create a
website for ourselves [including self-building through a University of Oxford
portal]. In December 2022, we were asked by NHSBT’s Chief Medical Officer to
join with JPAC and SHOT [both groups funded as we are through the UK Blood Services]
in a project to create new, independent websites for the three groups. During
the past nine months, we have done the following: · Understood that
is highly unlikely that any of the websites can be built in-house as they are
perceived to be of minimal value to NHSBT core operations. · Understood that
funding for the website development will not be available from within NHSBT’s
Clinical Directorate. · Worked with an
external company, TPX Impact, to understand the business and user needs and requirements
to support the build and implementation of new websites to replace the
existing sites. This research culminated in the creation of detailed Business
Requirement Documents for each website. · Presented the
work done thus far to our funders, UK Blood Services, in September 2023, and have
been surprised to be told that there is an underspend in their budget and
that we could use some of this underspend to create an SRI website by March
2024. · Begun working
with NHSBT Commercial on the process to contract with an external company to
build an SRI website. |
|
Influence on Policy |
We explored ‘influence on policy’ by searching for guidelines in
which our reviews have been cited since the last meeting. From September 2022 to
October 2023, 20 international guidelines have been published which have been
informed by 18 SRI systematic reviews (24 citations): 1. Multidisciplinary
paper on patient blood management in cardiothoracic surgery in the UK:
perspectives on practice during COVID-19 (2023) Al-Attar N, Gaer J, Giordano V, Harris E, Kirk A, Loubani M, et
al. Journal of Cardiothoracic Surgery. 2023;18(1 C7 - 96). 1 Systematic Review: Stanworth SJ, New HV, Apelseth TO, Brunskill S, Cardigan R,
Doree C, Germain M, Goldman M, Massey E, Prati D, Shehata N, So-Osman C,
Thachil J. Effects of the COVID-19 pandemic on supply and use of blood for
transfusion. The Lancet Haematology.
2020;7(10):e756-e64. PubMed ID: 32628911. 2. 2023 ESC
Guidelines for the management of acute coronary syndromes (2023) Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo
A, et al. European heart journal Acute cardiovascular care. 2023. 2 Systematic Reviews: 1) Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N,
Fergusson DA, Triulzi D, Dorée C, Hébert PC. Transfusion thresholds for
guiding red blood cell transfusion. Cochrane
Database of Systematic Reviews 2021;12:CD002042. PubMed ID: 34932836. 2) Simpson E, Lin Y, Stanworth S, Birchall J, Doree C, Hyde C.
Recombinant factor VIIa for the prevention and treatment of bleeding in
patients without haemophilia. Cochrane
Database of Systematic Reviews. 2012;(3):CD005011. PubMed ID: 22419303. 3. Guidelines
on the Use of Therapeutic Apheresis in Clinical Practice – Evidence-Based
Approach from the Writing Committee of the American Society for Apheresis:
The Ninth Special Issue (2023) Connelly-Smith L, Alquist CR, Aqui NA, Hofmann JC, Klingel R,
Onwuemene OA, et al. Journal of Clinical Apheresis. 2023;38(2):77-278. 1 Systematic Review: Brunskill SJ, Tusold A, Benjamin S, Stanworth SJ, Murphy MF. A
systematic review of randomized controlled trials for plasma exchange in the
treatment of thrombotic thrombocytopenic purpura. Transfusion Medicine (Oxford, England). 2007;17(1):17-35. PubMed
ID: 17266701. 4. ECCO
Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease
(2023) Gordon H, Burisch J, Ellul P, Karmiris K, Katsanos K, Allocca M,
et al. Journal of Crohn's and Colitis. 2023. 1 Systematic Review: Odutayo A, Desborough MJ, Trivella M, Stanley AJ, Dorée C,
Collins GS, Hopewell S, Brunskill SJ, Kahan BC, Logan RF, Barkun AN, Murphy
MF, Jairath V. Restrictive versus liberal blood transfusion for
gastrointestinal bleeding: a systematic review and meta-analysis of
randomised controlled trials. The
Lancet Gastroenterology & Hepatology. 2017;2(5):354-60. PubMed ID:
28397699. 5. NCCN
Clinical Practice Guidelines in Oncology: Hematopoietic Growth Factors,
Version 2.2023. Plymouth (PA): National Comprehensive Cancer Network; March
2023 (2023) Griffiths EA RV, Alwan L, Bachiashvili K, Baird J, Bakhshi S,
Cool R, Dinner S, Geyer M, Glaspy J, Gojo I, Grove M, Jung l
, Kidwai WZ, Kloth DD, Lyman GH, Mahajan A, Miller R, Nachar V, Patel
S, Patel H, Perez LE, Poust A, Riaz F, Rosovsky R, Rugo HS, Vasu S, Wadleigh
M, Westbrook K, Westervelt P, Pluchino LA, Dwyer M; National Comprehensive
Cancer Network. 2023. 2 Systematic Reviews: 1) Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N,
Fergusson DA, Triulzi D, Dorée C, Hébert PC. Transfusion thresholds for
guiding red blood cell transfusion. Cochrane
Database of Systematic Reviews. 2021;12:CD002042. PubMed ID:34932836. 2) Estcourt LJ, Stanworth SJ, Hopewell S, Doree C, Trivella M,
Massey E. Granulocyte transfusions for treating infections in people with
neutropenia or neutrophil dysfunction. Cochrane
Database of Systematic Reviews. 2016;(4):CD005339. PubMed ID: 27128488;
PMCID: PMC4930145. 6. Management
of severe peri-operative bleeding: Guidelines from the European Society of
Anaesthesiology and Intensive Care: Second update 2022 (2023) Kietaibl S, Ahmed A, Afshari A, Albaladejo P, Aldecoa C,
Barauskas G, et al. European Journal of Anaesthesiology.
2023;40(4):226-304. 1 Systematic Review: Brunskill SJ, Millette SL, Shokoohi A, Pulford EC, Doree C,
Murphy MF, Stanworth S. Red blood cell transfusion for people undergoing hip
fracture surgery. Cochrane Database of
Systematic Reviews. 2015;(4):CD009699. PubMed ID: 25897628. 7. Multidisciplinary
consensus document on the management of massive haemorrhage. First update
2023 (document HEMOMAS-II) (2023) Llau JV, Aldecoa C, Guasch E, Marco P, Marcos-Neira P, Paniagua
P, et al. Revista Espanola de Anestesiologia y Reanimacion.
2023;70(7):409-21. 1 Systematic Review: McQuilten ZK, Crighton G, Brunskill S, Morison JK, Richter TH,
Waters N, Murphy MF, Wood EM. Optimal Dose, Timing and Ratio of Blood
Products in Massive Transfusion: Results from a Systematic Review. Transfusion Medicine Reviews.
2018;32(1):6-15. PubMed ID: 28803752. 8. Multidisciplinary
consensus document on the management of massive haemorrhage. First update
2023 (document HEMOMAS-II) (2023) Llau JV, Aldecoa C, Guasch E, Marco P, Marcos-Neira P, Paniagua
P, et al. Medicina Intensiva. 2023;47(8):454-67. 1 Systematic Review: McQuilten ZK, Crighton G, Brunskill S, Morison JK, Richter TH,
Waters N, Murphy MF, Wood EM. Optimal Dose, Timing and Ratio of Blood
Products in Massive Transfusion: Results from a Systematic Review. Transfusion Medicine Reviews. 2018;32(1):6-15.
PubMed ID: 28803752. 9. Diagnostic
and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) in
Japan 2023 (2023) Matsumoto M, Miyakawa Y, Kokame K, Ueda Y, Wada H, Higasa S, et
al. International Journal of Hematology. 2023. 1 Systematic Review: Docherty AB, O'Donnell R, Brunskill S, Trivella M, Doree C,
Holst L, Parker M, Gregersen M, Pinheiro de Almeida J, Walsh TS, Stanworth
SJ. Effect of restrictive versus liberal transfusion strategies on outcomes
in patients with cardiovascular disease in a non-cardiac surgery setting:
systematic review and meta-analysis. BMJ. 2016;352: i1351. PubMed ID:
27026510. 10. Current
advances in 2022: A critical review of selected topics by the Association for
the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion
Medicine Committee (2023) Metcalf RA, Cohn CS, Bakhtary S, Gniadek T, Gupta G, Harm S, et
al. Transfusion. 2023;63(8):1590-600. 1 Systematic Review: McCullagh J, Cardigan R, Brunskill SJ, Bullock T, Doree C,
Estcourt L, Huish S, Sandercock J, Green L Assessing the risks of haemolysis
as an adverse reaction following the transfusion of ABO incompatible
plasma-containing components - A scoping review. Blood Reviews. 2022:100989. PubMed ID: 35871104. 11. Fresh frozen
plasma administration in the NICU: evidence-based guidelines. (2023) Motta MG, B. Current Pediatric Review. 2023;19(4):342-51. 1 Systematic Review: Desborough M, Sandu R, Brunskill SJ, Doree C, Trivella M,
Montedori A, Abraha I, Stanworth S. Fresh frozen plasma for cardiovascular
surgery. Cochrane Database of
Systematic Reviews, 2015;(7) ,CD007614. PubMed
ID: 26171897. 12. Trombocytentransfusies
bij kinderen met kanker. [Guideline: Platelet transfusions in children with
cancer]. Utrecht: Federatie Medisch Specialisten; June 2022. (2022) [Paediatrics]
NVvKDAf. 2022. 2 Systematic Reviews: 1) Crighton GL, Estcourt LJ, Wood EM, Trivella M, Doree C,
Stanworth S. A therapeutic-only versus prophylactic platelet transfusion
strategy for preventing bleeding in patients with haematological disorders
after myelosuppressive chemotherapy or stem cell transplantation. Cochrane Database of Systematic Reviews.
2015;2015(9):CD010981. PubMed ID: 26422767; PMCID: PMC4610062. 2) Estcourt LJ, Stanworth SJ, Doree C, Hopewell S, Trivella M,
Murphy MF. Comparison of different platelet count thresholds to guide administration
of prophylactic platelet transfusion for preventing bleeding in people with
haematological disorders after myelosuppressive chemotherapy or stem cell
transplantation. Cochrane Database of
Systematic Reviews. 2015;2015(11):CD010983. PubMed ID: 26576687; PMCID:
PMC4717525. 13. The European
guideline on management of major bleeding and coagulopathy following trauma:
sixth edition (2023) Rossaint R, Afshari A, Bouillon B, Cerny V, Cimpoesu D, Curry N,
et al. Critical Care (London, England). 2023;27(1):80. 2 Systematic Reviews: 1) Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N,
Fergusson DA, Triulzi D, Dorée C, Hébert PC. Transfusion thresholds for
guiding red blood cell transfusion. Cochrane
Database of Systematic Reviews. 2021;12:CD002042. PubMed ID:34932836. 2) Simpson E, Lin Y, Stanworth S, Birchall J, Doree C, Hyde C.
Recombinant factor VIIa for the prevention and treatment of bleeding in
patients without haemophilia. Cochrane
Database of Systematic Reviews. 2012;(3):CD005011. PubMed ID: 22419303. 14. Intravenous
iron administration in Home Hospitalization Units: Good practice
recommendations (2023) Ruiz-Castellano M, Jericó C, García-Erce JA. Medicina Clinica.
2023. 1 Systematic Review: Neoh K, Page A, Chin-Yee N, Doree C, Bennett MI. Practice
review: Evidence-based and effective management of anaemia in palliative care
patients. Palliative Medicine.
2022:2692163221081967. PubMed ID: 35331051. 15. Management
of Patients With Acute Lower Gastrointestinal
Bleeding: An Updated ACG Guideline (2023) Sengupta N, Feuerstein JD, Jairath V, Shergill AK, Strate LL,
Wong RJ, et al. The American Journal of Gastroenterology.
2023;118(2):208-31. 1 Systematic Review: Odutayo A, Desborough MJ, Trivella M, Stanley AJ, Dorée C,
Collins GS, Hopewell S, Brunskill SJ, Kahan BC, Logan RF, Barkun AN, Murphy
MF, Jairath V. Restrictive versus liberal blood transfusion for
gastrointestinal bleeding: a systematic review and meta-analysis of
randomised controlled trials. The Lancet
Gastroenterology & Hepatology. 2017;2(5):354-60. PubMed ID: 28397699. 16. Recommendations
From the International Consensus Conference on Anemia Management in Surgical
Patients (ICCAMS) (2023) Shander A, Corwin HL, Meier J, Auerbach M, Bisbe E, Blitz J, et
al. Annals of Surgery. 2023;277(4):581-90. 1 Systematic Review: Shah AA, Donovan K, Seeley C, Dickson EA, Palmer AJR, Doree C,
Brunskill S, Reid J, Acheson AG, Sugavanam A, Litton E, Stanworth SJ. Risk of
Infection Associated With Administration of Intravenous
Iron: A Systematic Review and Meta-analysis. JAMA Network Open. 2021;4(11):e2133935.
PubMed ID: 34767026. 17. Primary
prophylaxis of invasive fungal diseases in patients with haematological
malignancies: 2022 update of the recommendations of the Infectious Diseases
Working Party (AGIHO) of the German Society for Haematology and Medical
Oncology (DGHO) (2023) Stemler J, Mellinghoff SC, Khodamoradi Y, Sprute R, Classen AY,
Zapke SE, et al. The Journal of Antimicrobial Chemotherapy.
2023;78(8):1813-26. 1 Systematic Review: Estcourt LJ, Stanworth S, Doree C, Blanco P, Hopewell S,
Trivella M, Massey E. Granulocyte transfusions for preventing infections in
people with neutropenia or neutrophil dysfunction. Cochrane Database of Systematic Reviews. 2015(6):CD005341. PubMed
ID: 26118415; PMCID: PMC4538863. 18. Australian
Guidelines for the Clinical Care of People with COVID-19 (2023). Taskforce
ANC-CE. 2023;v.71. 1 Systematic Review: Piechotta V, Iannizzi C, Chai KL, Valk SJ,
Kimber C, Dorando E, Monsef I, Wood EM,
Lamikanra AA, Roberts DJ, McQuilten Z, So-Osman C,
Estcourt LJ, Skoetz N. Convalescent plasma or hyperimmune
immunoglobulin for people with COVID‐19: a living systematic review. Cochrane Database of Systematic Reviews.
2021(5):CD013600. PubMed ID: 34013969. 19. КЛІНІЧНЕ
ВЕДЕННЯ
ПАЦІЄНТІВ З
COVID-19 «ЖИВА» КЛІНІЧНА
НАСТАНОВА. [Clinical
management of patients with COVID-19. Living clinical guidelines]. Kiev,
Ukraine: The State Expert Center of the Ministry of Health of Ukraine; 2023.
[Issued January 2021; last updated May 2023]. (2023) Ukraine TSECotMoHo. 2023. 1 Systematic Review: Valk SJ, Piechotta V, Chai KL, Doree C, Monsef I, Wood EM,
Lamikanra A, Kimber C, McQuilten Z, So-Osman C, Estcourt LJ, Skoetz N.
Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a
rapid review. Cochrane Database of
Systematic Reviews. 2020;(7):CD013600. PubMed ID: 32406927; PMCID:
PMC7271896. 20. EASL
Clinical Practice Guidelines on prevention and management of bleeding and
thrombosis in patients with cirrhosis (2022) Villa E, Bianchini M, Blasi A, Denys A, Giannini EG, de Gottardi
A, et al. Journal of Hepatology. 2022;76(5):1151-84. 1 Systematic Review: Stanworth SJ, Brunskill SJ, Hyde CJ, McClelland DB, Murphy MF.
Is fresh frozen plasma clinically effective? A systematic review of
randomized controlled trials. British
Journal of Haematology. 2004;126(1):139-52. PubMed ID: 15198745. |
|
Research Tools & Methods |
NIHR Cochrane
programme grant [2].
We have used a form of analysis, network meta-analysis (NMA), for the systematic
reviews being undertaken through our NIHR Cochrane programme grant. This is the first time we have used this
form of analysis. All working on the programme grant attended specific NMA
training both in Oxford in June 2019 and Bristol in December 2019. We initially received support from both the
Cochrane Complex Reviews Unit and Professor Nicky Welton from the University
of Bristol for this form of analysis. In the last 12 months, external support
for the NMA work has come from Professor Alex Sutton and Clareece Nevill at
the University of Leicester and NIHR Complex Reviews Support Unit (CRSU),
principally related to the software MetaInsight. Josie Sandercock found a
simple method for getting MetaInsight to run locally, a necessity for very
large networks, which is now part of the MetaInsight user guide. The elective
orthopaedic surgery review was analysed using BUGSnet in R due to limitations
in MetaInsight, but the latest (Sept 2023) version of MetaInsight is being
used for the cardiac surgery review because BUGSnet cannot handle the size of
the network in this review. Josie Sandercock found a simple method to
identify nodes which break the network in an NMA, a previously time-consuming
problem for very large networks, and CRSU are developing an R package to
implement this. We use Covidence for all our screening activities and had
used Covidence to undertake data extraction for the Cochrane reviews in our
NIHR Cochrane Programme Grant and our smaller systematic reviews. However,
having had significant issues with extracting data using this software, we
are currently not using Covidence for data extraction. As a result, we have been exploring using other software,
specifically that available through SR
Accelerator, https://sr-accelerator.com/#/.
Members of the team have used two of its programmes, Spidercite and Screenatron,
and we hope to run a full review through the resources available on SR
Accelerator within the next year. |
|
Research Databases & Models |
See section below: Software
& Technical Products |
|
Intellectual Property & Licensing |
Conversations with NHSBT Procurement over the past two years
have highlighted that aspects of our Electronic Libraries
should be registered as intellectual property, most specifically the database
structure. The current structure of the database was developed by Evidentia
Publishing and they do not think it is appropriate to apply for intellectual
property for the database structure. There was interest within NHSBT in bringing the development and
hosting of both electronic libraries in-house and, should that happen, we
could explore registering intellectual property rights for the new structure
of the electronic libraries. However, conversations during 2023 have
highlighted that whilst there is interest from a database architecture and
design perspective, there is no interest from decision-makers within NHSBT
responsible for investment in resources and therefore we will not be bringing
the development and hosting of both electronic libraries in-house. |
|
Medical Products, Interventions and Clinical
Trials |
Clinical Trials
that have developed from one of our systematic reviews in the past 12 months:
· REVIEW: What is the effect of perioperative
intravenous iron therapy in patients undergoing non-elective surgery? [2018]
Clinical Trials that have developed/ been
informed by one of our systematic reviews: ·
REVIEW: The Difference in
Potential Harms between Whole Blood and Component Blood Transfusion in major
Bleeding: A Rapid Systematic Review and Meta-Analysis of RCT [2022]. clinical effectiveness and
cost-effectiveness of pre-hospital whole
blood administration versus standard care for traumatic haemorrhage- rapid
review Trial
status: starting to open for recruitment. · REVIEW: Anti-fibrinolytics for the
prevention of bleeding in patients with haematological malignancies
[2016]: The recent
update of this review was referenced in
the following trial: malignancies.[ClinicalTrials.gov
Identifier: NCT03136445. Analysis of the trial data has been completed and a
publication is expected
in spring 2024. Awarding Body: NHSBT. · REVIEW: Gaps in the
evidence for prevention and treatment of maternal anaemia: a review of
systematic reviews [2012]: ·
REVIEW:
Granulocytes for treating infection [2016]:
|
|
Artistic & Creative Products |
Nothing to report. |
|
Transfusion Evidence
Library (www.transfusionevidencelibrary.com).
As of October 2023, the library contains 15,059 records. Of those 10,268 are RCTs, 4,557 are
Systematic Reviews and 100 are Economic Studies. Annual maintenance bill= £ 25,000. The Transfusion Evidence
Library has the facility to highlight Featured Articles, and this year this functionality
was used to display 113 articles conducted by the SRI team to highlight the
20th anniversary of the SRI. Four Transfusion
Evidence Round-Ups were emailed for the following awareness days: The Best of the Transfusion Evidence Library (5th
December 2022), World Haemophilia Day (6th March 2023), World
Blood Donor Day (14th June 2023), World Heart Day (29th
September 2023). Transfusion
Evidence Library usage (taken from Google Analytics data) · Between
October 2022 and September 2023, the Transfusion Evidence Library (TEL) was
visited from more than 130 countries; the TEL had 11,102 users, which is an
increase in 10% in the number of users from the same period last year. · Between
October 2022 and September 2023, TEL users by country were: 37% from USA, 11%
from UK, 6% from Australia, 5% from Canada, 4% from Germany, and 2% each from
Netherlands, Italy, and India. Like the previous year, the USA was the
country from where most visits originated. · Most
users (86%) came to TEL directly or by typing the URL. 5% of users arrived
from social media (Twitter/X or Facebook), and 4% each arrived from searching
the internet and via links sent through emails. Transfusion
Evidence Alert We have 8,637 subscribers to the Transfusion Evidence Alert. Transfusion
Evidence Library on Twitter (now X) (@TransfusionLib). On 26th September 2023, Transfusion
Evidence Library had 3,294 followers [a slight rise from the previous year].
Tweets are posted about monthly email alerts and their contents, relevant
awareness days, news items that contain content relevant to the Transfusion
Evidence Library, as well as retweeting tweets from the SRI and SCE Twitter/X
streams as relevant. We have also
publicised the Transfusion Evidence Round-Ups through the TEL Twitter/X
account, and through the TEL Facebook page.
We are continuing to monitor the situation with Twitter/X and have
explored other options for social media.
We have set up Mastodon accounts for both libraries. A link to the Transfusion Evidence Library website link can be
found on 656 sites, including the following: ·
British Blood Transfusion Society: ·
NHSBT Library, Evidence Search section. ·
Canadian Society for Transfusion Medicine: ·
Institute of Scientific Information, Charles University, First Faculty
of Medicine and General University Hospital in Prague ·
Wikipedia article [External Links]: ·
NHS Leeds Libraries: ·
NHS Velindre University: ·
Pavol Jozef Safarik University, Kosice, Slovak Republic ·
National Medical Library, Prague ·
LinkedIn: ·
mentioned on the ISBT website. Other dissemination: · A report with
the monthly content uploaded in TEL is emailed to the editor of Transfusion Medicine Reviews. · A report is
emailed every six months to with the content uploaded in TEL to the Royal
College of Pathologists. Transfusion
Evidence Library has been cited in the following 26 publications since
October 2021: 1. Aceto P, Punzo G, Di Franco V,
Teofili L, Gaspari R, Avolio AW, et al. Viscoelastic versus conventional
coagulation tests to reduce blood product transfusion in patients undergoing liver
transplantation: A systematic review and meta-analysis. Eur J Anaesthesiol.
2023;40(1):39-53. PubMed ID: 36412263. 2. Al-Riyami AD, S; Saxon,
B; Rahimi-Levene, N; Vanden Broeck, J; So-Osman, C; Lin, Y; Stanworth, S.
E-learning in transfusion medicine: A scoping review. Vox Sanguinis.
2023;118(S1):Abstract No. P022. Supplement:
Abstracts of the 33rd Regional Congress of the ISBT Gothenburg, Sweden 17–21
June 2023. 3. Allen G. Intraoperative Transfusion
Strategies: A Systematic Review and Meta-Analysis. AORN Journal.
2022;116(6):587-91. 4. Avau B, O D, Veys K,
Georgsen J, Nahirniak S, Shehata N, et al. Systematic reviews on platelet
transfusions: Is there unnecessary duplication of effort? A scoping review.
Vox Sanguinis. 2023;118(1):16-23. PubMed ID: 36454598. 5. Beverly A, Ong G, Kimber C,
Sandercock J, Doree C, Welton NJ, et al. Drugs to reduce bleeding and
transfusion in major open vascular or endovascular surgery: a systematic
review and network meta-analysis. Cochrane Database of Systematic Reviews.
2023;2:CD013649. PubMed ID: 36800489. 6. Brunskill SM, A; Kimber,
C; Estcourt, L; Plaza Cajide, A; Doree, C; Clarke, G; White, J; Wood, E. . Introducing 'Transfusion Evidence Round-Ups’: An ISBT
and systematic review initiative collaboration with a goal to share knowledge
to improve transfusion practice worldwide. Vox Sanguinis. 2023;118(S1):Abstract No. P023. Supplement: Abstracts of the 33rd
Regional Congress of the ISBT Gothenburg, Sweden 17–21 June 2023. 7. Dhiman P, Ma J, Gibbs
VN, Rampotas A, Kamal H, Arshad SS, et al. Systematic review highlights high
risk of bias of clinical prediction models for blood transfusion in patients
undergoing elective surgery. J Clin Epidemiol. 2023;159:10-30.
PubMed ID: 37156342. 8. Erasu V, Novak A, Gibbs VN, Champaneria
R, Dorée C, Hafeez A, et al. Pharmacological interventions for the treatment
of bleeding in people treated for blunt force or penetrating injury in an
emergency department: a systematic review and network meta‐analysis
[Protocol]. Cochrane Database of Systematic Reviews. 2022(6):CD014600. 9. Gibbs VN, Geneen LJ, Champaneria R,
Raval P, Doree C, Brunskill SJ, et al. Pharmacological interventions for the
prevention of bleeding in people undergoing definitive fixation or joint
replacement for hip, pelvic and long bone fractures. Cochrane Database of
Systematic Reviews. 2023(6):CD013499. PubMed ID: 37272509. 10. Kimber C, Lamikanra AA, Geneen LJ,
Sandercock J, Dorée C, Valk SJ, et al. A systematic review of the safety and
efficacy of convalescent plasma or immunoglobulin treatment for people with
severe respiratory viral infections due to coronaviruses or influenza.
Transfusion Medicine. 2023;33(1):26-38. PubMed ID: 36412541. 11. Laermans J, Van
Remoortel H, Scheers H, Avau B, Georgsen J, Nahirniak S, et al. Cost
Effectiveness of Different Platelet Preparation, Storage, Selection and
Dosing Methods in Platelet Transfusion: A Systematic Review.
PharmacoEconomics - Open. 2023;7(5):679-708. PubMed ID: 37365482. 12. Lenet T, Baker L, Park
L, Vered M, Zahrai A, Shorr R, et al. A Systematic Review and Meta-analysis
of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell
Transfusion Strategies. Annals of Surgery. 2022;275(3):456-66. PubMed ID:
34319671. 13. Lewis SR, Pritchard MW, Estcourt
LJ, Stanworth SJ, Griffin XL. Interventions for reducing red blood cell
transfusion in adults undergoing hip fracture surgery: an overview of
systematic reviews. Cochrane Database of Systematic Reviews.
2023(6):CD013737. PubMed ID: 37294864. 14. Lin J-WL, C-I; Cheng,
H-M; Lin, S-L; Liu, C-Y; Hsu, T-F. Hemoglobin threshold for blood transfusion
among chronic anemic patients: a meta-analysis and implementation of Choosing
Wisely campaign. Journal of Taiwan Empirical Medicine Society. 2022;13(2):58-85.
15. Lin VS, E; Yau, S;
Abeyakoon, C; Seamer, G; Bhopal, S; Tucker, H; Doree, C; Brunskill, S;
Mcquilten, Z;Stanworth, SJ; Wood, E; Green, L. What
is a massive transfusion? A scoping review to inform an international
consensus definition. HemaSphere. 2023;7:e4792419.
Abstract No. S304. Supplement 16. Lin VS, Sun E, Yau S, Abeyakoon C,
Seamer G, Bhopal S, et al. Definitions of massive transfusion in adults with
critical bleeding: a systematic review. Crit Care. 2023;27(1):265. PubMed ID:
37407998. 17. Lloyd TD, Geneen LJ,
Bernhardt K, McClune W, Fernquest SJ, Brown T, et al. Cell salvage for
minimising perioperative allogeneic blood transfusion in adults undergoing
elective surgery. Cochrane Database of Systematic Reviews. 2023(9):CD001888.
PubMed ID: 37681564. 18. Meyer CH, Bailey NM,
Leslie SL, Thrasher K, Grady Z, Sanders M, et al. Defining ultra-massive
transfusion through a systematic review. American Journal of Surgery. 2023:
Article in Press. 19. Mo A, Poynton M, Wood
E, Shortt J, Brunskill SJ, Doree C, et al. Do anemia treatments improve
quality of life and physical function in patients with myelodysplastic
syndromes (MDS)? A systematic review. Blood Reviews. 2023;61:101114.
PubMed ID: 37479599. 20. Mo A; Poynton MW, E.;
Shortt, J; Brunskill, S; Doree, C; Sandercock, J; Saadah, N; Luk, E;
Stanworth, S; McQuilten, Z. Does treatment of anaemia improve quality of life
or physical function for patients with myelodysplastic syndromes (MDS): a
systematic review. Vox Sanguinis. 2023;118(S1): Abstract No. P446 Supplement: Abstracts of the 33rd
Regional Congress of the ISBT Gothenburg, Sweden 17–21 June 2023. 21. Neary E, Murphy CA, Ní
Áinle F, El-Khuffash A, Cotter M, Kirkham C, et al. Plasma transfusion to
prevent intraventricular haemorrhage in very preterm infants [Protocol].
Cochrane Database of Systematic Reviews. 2023(5):CD012341. PubMed ID: 22. Pagano MB, Dennis JA,
Idemudia OM, Stanworth SJ, Carson JL. An analysis of quality of life and functional
outcomes as reported in randomized trials for red cell transfusions.
Transfusion. 2023: Online ahead of print. PubMed ID: 37723866. 23. Rajendran L, Lenet T,
Shorr R, Abou Khalil J, Bertens KA, Balaa FK, et al. Should Cell Salvage Be
Used in Liver Resection and Transplantation? A Systematic Review and
Meta-analysis. Annals of surgery. 2023;277(3):456-68. PubMed ID: 35861339. 24. Roy NBA, Carpenter A, Dale-Harris
I, Dorée C, Estcourt LJ. Interventions for chronic kidney disease in people
with sickle cell disease. Cochrane Database of Systematic Reviews.
2023(8):CD012380. PubMed ID: 37539955. 25. Schofield J,
Hosseinzadeh S, Burton K, Pavord S, Dutt T, Doree C, et al. Drug-induced
thrombotic thrombocytopenic purpura: A systematic review and review of
European and North American pharmacovigilance data. British Journal of
Haematology. 2023;201(4):766-73. PubMed ID: 36477772. 26. Van Remoortel H,
Scheers H, Avau B, Georgsen J, Nahirniak S, Shehata N, et al.
Cost-Effectiveness of Thrombopoietin Mimetics in Patients with
Thrombocytopenia: A Systematic Review. PharmacoEconomics. 2023;41(8):869-911.
PubMed ID: 37145291. Stem Cell Evidence www.stemcellevidence.com As
of September 2023, the library contains 12,911 records (a rise of ~1200),
including 535 RCTs, 649 systematic reviews, and 281 guidelines. From November
2022, Stem Cell Evidence has the facility to highlight Featured Articles,
using the functionality developed to display COVID-19 records. Stem Cell Evidence usage (taken from Google Analytics data).
In the past year (from October 2022 to September 2023), Stem Cell Evidence
has had 6,292-page views from 2,262 individual users, from more than 70
countries. · Stem Cell Evidence users
by country were: 29% from UK, 25% from USA, 4% from Netherlands, 3% each from
China, Australia, Mexico and India, and 2% each from Germany, Portugal and
Italy. · Most users (87%) came to Stem Cell Evidence directly, either
by typing the URL or using a bookmark; 6% of users arrived by social media,
and 5% of users arrived by searching the internet. Stem Cell Evidence Alert. We have 1,252 subscribers to the Stem Cell
Evidence Alert. Stem Cell Evidence on
Twitter/X (@evidencestemc). On 18th October 2021 Stem Cell Evidence had
547 followers [a 8% rise from the previous
year]. Tweets are posted about monthly
email alerts and their contents, relevant awareness days, news items that
contain content relevant to Stem Cell Evidence as well as retweeting tweets
from the SRI and TEL Twitter/X streams as relevant. We continue to monitor the situation with
Twitter/X and have set up a Mastodon account for the libraries. A link to Stem Cell Evidence can be found on 33 websites,
including · Albertina
icome Praha · Cochrane
Haematology · Canterbury
Christ Church University |
|
|
Awards and Recognition |
People ·
Lise Estcourt has
been awarded the 2023 Kenneth Goldsmith Award
from the British Blood Transfusion Society. |
|
Use of Facilities & Resources |
Resources: We continue to use Covidence for all
our screening activities and although have used Covidence to undertake data
extraction for the Cochrane reviews in our NIHR Cochrane Programme Grant and some
smaller systematic reviews, we have not yet tried the updated Covidence for
data extraction on large reviews or on reviews where the data is complex or
when some customisation of the preformatted Covidence data sheets is needed.
We have therefore chosen not to use Covidence exclusively for data
extraction. Training Received: SRI team members have attended the following training activities
since 1st November 2022: Susan Brunskill · Attended “Cochrane New review format” webinar,
November 2022 · Attended NHS Elect updates for leaders, four 1 hour workshops through November 2022 · Attended “Exporting data (Extraction 1) in Covidence”
webinar, May 2023 · Attended Cochrane Colloquium, September 2023
attending workshops on scoping reviews, how to undertake overviews of
systematic reviews, conducting rapid qualitative evidence synthesis and oral
sessions on evidence synthesis and RoB2, risk of bias analysis of qualitative
studies and methodological quality and evidence synthesis innovation. Carolyn
Doree · Deduklick: automated deduplication using AI
workshop. Risklick, September 2022 · What’s going on with my search? Database quirks and
expert searching in the health sciences. University of Michigan, October 2022 · Cochrane new review format webinar, November 2022 · Finding search filters for study designs: using the
ISSG Search Filter Resource. Julie Glanville, June 2023 · ClinicalTrials.gov for Librarians (Advanced). NLM,
August 2023 · NLM What's new in Pubmed? NLM, August 2023 · Attended Cochrane Colloquium: workshops on searching
for rapid reviews, WHO ICTRP, and how to use Shiny Apps in information
retrieval (September 2023) Louise
Geneen ·
Participation
in development of RMW Porto and RMW development demonstrations (fortnightly
meetings, 22April 2022 – ongoing) · Interview: gave feedback on development of RevManWeb team
(one-to-one, online, various times) · Attended NHSBT R&D conference (October 2023) · Attended Cochrane Colloquium: workshops on scoping reviews, GRADE
rating of imprecision, and analysis of interrupted-time-series studies (Sept
2023). · Edward Jenner: 3 – Leading in and beyond my team (NHS Leadership
Academy) (June 2023 – ongoing) · Edward Jenner: 2 – Leading through relationships (NHS Leadership
Academy) (April-June 2023) · Edward Jenner: 1 – Exploring what leadership means to me (NHS
Leadership Academy) (Jan-Mar 2023) · Edward Jenner: 0 – An introduction to Personal Development (NHS
Leadership Academy) (Jan 2023) Catherine Kimber ·
Attended
“Cochrane New review format” webinar, November 2022 ·
Attended
“PRISMA reporting and Covidence” webinar, 20th April 2023 ·
Undertook
online course “Cochrane Interactive Learning Module 10: Network
Meta-Analysis, May 2023 ·
Attended
and participated in 8th Course on Network Meta-Analysis, 19th-21st
June 2023 ·
Attended
“NHSBT Clinical R&D Conference" 2nd & 3rd
October 2023 Alicia Plaza-Cajide · Good Practice with Images course (June 2023), IT
Learning Centre, University of Oxford. · Posters: Improving your research posters course
(June 2023), IT Learning Centre, University of Oxford. · iSkills for the Medical Sciences Division and OUH
Trust: Introduction to searching: how to find literature on a topic in
medicine and health care (June 2023), IT Learning Centre, University of
Oxford. · Exploring
Stress in our Behaviour Webinar by The Healthy Employee Ltd, (January 2023),
via NHSBT. · Illustrations:
Effective workflows (InkScape) course (November 2022), IT Learning Centre,
University of Oxford. Josie Sandercock ·
Undertaken own learning and
development in Network Meta-analysis and R. · Attended
Cochrane Colloquium: (September 2023) · Attended NHSBT R&D conference (October 2023) Rita
Solanki · Attended ‘NHSBT Research and
Development Conference’, 3rd October 2023 · Attended ‘Statistics and Clinical
Research seminar series’ – ‘Patient Blood Management’, 12th
September 2023 · Attended ‘Statistics and Clinical
Research seminar series’ – ‘Our Voice Results’, 4th July 2023 |
|
Other Outputs & Knowledge |
The
information science workload has remained constant this past year. In
addition to the core search activities for our reviews and the libraries, during
2022/3, Carolyn has also given full information science support to the
following projects (with costs recovered for the SRI):.
i.
BTRU Economic studies in blood transfusion
scoping review – search strategy design and full search (Simon Stanworth,
October 2022)
ii.
Search
strategy design to support the publication of the DASH (Desmopressin
for Intracerebral Haemorrhage) trial ahead of Lancet publication (Mike
Desborough, Aprile 2023). iii.
Risk of infection associated with intravenous iron
preparations: update search (Akshay Shah, September 2023)
iv.
BTRU
Data Driven Transfusion Practice: The Impact of Blood Transfusion on
Recurrence and Mortality Following (Solid) Cancer Surgery/Resection search
strategy design and full search, (Simon Stanworth, November 2022; update
search October 2023).
v.
Jeff
Carson’s Transfusion Thresholds review (Cochrane), update search, (Simon
Stanworth, August 2023). |