New Publication: ABO matching for platelet transfusions

Our most recently published systematic review explores whether there is a difference in outcomes [clinically significant (WHO grade 2+ and 3+) bleeding, mortality, acute transfusion reactions, platelet refractoriness] when comparing ABO-identical and non-identical (major, minor, bi-directional mismatch) platelet transfusions. The reason for the review is that whilst transfusion of ABO identical platelets is recommended in national guidelines, transfusion of ABO non-identical platelets has been widely adopted to ensure availability and reduce wastage. When ABO non-identical platelets are necessitated, there is a lack of consensus on prioritisation of major or minor compatibility.